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Objective@#To explore the distribution of Traditional Chinese Medicine (TCM) syndrome types and their relationship with semen parameters in infertility male patients with varicocele (VC).@*METHODS@#Using Questionnaire on Clinical Symptoms of Varicocele-Caused Male Infertility, we made an investigation among 147 infertility male patients with VC, determined the types of their TCM syndromes, obtained their semen parameters, and analyzed the distribution of the TCM syndrome types and their correlation with semen parameters.@*RESULTS@#Of the TCM syndrome types identified, kidney deficiency and stagnated heat constituted the largest proportion (34.7%), and the mixed type accounted for a significantly higher percentage than the simple type (P < 0.05). The patients with kidney deficiency and stagnated heat, compared with those with other syndrome types, had a dramatically lower sperm concentration (［21.62 ± 9.25］ vs ［28.88 ± 12.92］ ×10⁶/ml, P < 0.01), but a higher percentage of morphologically abnormal sperm (［98.33 ± 0.15］% vs ［96.27 ± 0.18］%, P < 0.05) and DNA fragmentation index (［19.72 ± 3.17］% vs ［10.96 ± 3.82］%, P < 0.01). No statistically significant differences were observed in the percentage of progressively motile sperm among different TCM syndrome types.@*CONCLUSIONS@#Kidney deficiency and stagnated heat is a main TCM syndrome type in infertility male patients with varicocele and correlated with sperm concentration, the percentage of morphologically abnormal sperm and DNA fragmentation index.
Subject(s)
Humans , Male , DNA Fragmentation , Infertility, Male/diagnosis , Medicine, Chinese Traditional , Semen , Semen Analysis , Sperm Count , Sperm Motility , Spermatozoa , Syndrome , Varicocele/diagnosisABSTRACT
Objective: To investigate the correlation between Ras homolog gene family member A (RhoA) gene in Wnt/PCP signaling pathway and acute exacerbation chronic obstructive pulmonary disease (AECOPD) traditional Chinese medicine(TCM)syndrome, attempting to provide an objective standard for the diagnosis of AECOPD TCM syndrome. Method: The 100 AECOPD patients were collected and divided into 5 groups:phlegm turbid obstructing lung syndrome,, phlegm-heat obstructing lung syndrome, syndrome of orifices confused by phlegm, deficiency of pulmonary and renal Qi, and edema due to yang deficiency, with 20 people in each group. 15 normal people were selected as a normal control group. All patients received fasting hemospasia, using a kit to extract blood total RibonucleicA(RNA) according to instructions. Real-time quantitative polymerase chain reaction (Real-time PCR) was adopted to detect the mRNA expression of RhoA gene in blood of patients with AECOPD TCM syndrome, and to explore the correlation. Result: There was no difference between phlegm-heat obstructing lung syndrome group and syndrome of orifices confused by phlegm group. The mRNA expression of RhoA gene in phlegm turbid obstructing lung syndrome group, phlegm-heat obstructing lung syndrome group, syndrome of orifices confused by phlegm group, deficiency of pulmonary and renal Qi group, and edema due to Yang deficiency group were significantly higher than that in normal group (PConclusion: The significant difference in mRNA relative expression of RhoA gene in Wnt/PCP signaling pathway among the five AECOPD TCM syndrome groups may provide some objective diagnostic criteria for AECOPD TCM syndromes and reveal their disease severity.
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In order to understand the characteristics of traditional Chinese medicine（TCM） syndrome types, the typical symptoms of different patients and the analysis of professor MA's medication characteristics of the treatment for infertility patients were analyzed. Totally 40 cases of infertile women treated in Xiyuan hospital and TCM out-patient department of China Academy of Chinese Medical Sciences in the past five years were randomly selected to classify their symptoms, signs and the four diagnostic situations in the first diagnosis, summarize syndromes and typical symptoms and analyze the characteristics of medication with Ma. Randomly selected nearly five years in 40 cases of infertile women with China Academy of Chinese Medical Sciences Xiyuan hospital and Chinese medicine out-patient department treatment, first diagnosed by symptoms, signs and the four diagnostic situation. According to the results, kidney yang deficiency： 10 cases (25%), kidney yin deficiency： 6 cases (15%), phlegm dampness： 3 cases (7.5%), liver qi stagnation： 3 cases (7.5%), blood stasis in the uterus： 7 cases (17.5%), deficiency of kidney yin deficiency and phlegm dampness： 1 cases (2.5%), kidney yin deficiency syndrome of liver qi stagnation： 2 cases (accounted for 5%), deficiency of kidney yang deficiency syndrome of liver qi stagnation： 1 cases (2.5%), phlegm dampness syndrome of liver qi stagnation：1 cases (2.5%), kidney yin deficiency syndrome, blood stasis and stagnation in the uterus 2 cases (accounted for 5%), liver qi stagnation syndrome and blood stasis in the uterus 2 cases (accounted for 5%), deficiency of kidney yang deficiency syndrome of liver qi stagnation syndrome and blood stasis in the uterus, 1 cases (2.5%). Typical symptoms were dominated by backache, pain and cold in the lower abdomen, followed by thirst, dry throat, more menstrual blood clots, more petechial hemorrhages at tongue, dysphoria, premenstrual breast pain, irritability, chest distress and greasy in mouth, leucorrhea, semiliquid stool or coprostasis. 40 cases of infertility patients showed obvious curative effect after the treatment of professor Ma's medication.
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Objective To analyze syndrome types and TCM prescriptions of Behcet's disease;To summarize the regularity of TCM syndrome differentiation and treatment principles of Behcet's disease.Methods Related literature in CNKI and VIP database from Jan. 1990 to Oct. 2013 was searched. The syndrome patterns, characteristics of prescriptions and frequency of syndrome were summarized.Results There were 20 syndrome types of Behcet's disease in the 58 collected literature. Damp and hot accumulating poison, spleen and kidney Yang deficiency, liver and kidney Yin deficiency, and hot and damp were common syndromes, occupying 55.4%. Hot and damp occupied 41.3%;Yin deficiency occupied 18.1%;Yang deficiency occupied 12.9%. Liver, spleen and kidney were the main disease locations, occupying 94.4%. There were 197 Chinese herbs in total, and could be classified and further combined into 19 types, among which heat-clearing drugs, tonics, activate blood and removing blood stasis were commonly adopted, occupying 50.6%. There were 66 prescriptions collected, among which 31 were set prescriptions, and 35 were prescriptions formed by self-experience. Longdan Xiegan Decoction and Gancao Xiexin Decoction were commonly adopted.Conclusion Syndrome types and TCM prescription characteristics of Behcet's disease had certain regularity, which can provide reference for clinical diagnosis and treatment.
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Objective To investigate the characteristics of TCM syndrome types in restenosis after percutaneous coronary intervention (PCI) of coronary heart disease, and explore the distribution law. Methods Sixty-two patients with coronary heart disease after PCI were selected. After 6 months of PCI, 62 patients were divided into restenosis group and non-restenosis group by coronary angiography. TCM syndrome types of the two groups were observed. Results There were 21 cases (33.87%) in restenosis group and 41 cases in non-restenosis group. In the deficiency syndrome, the dominant syndrome types were qi deficiency syndrome in two groups. The incidence of yang deficiency in restenosis group was higher than that in non-restenosis group (P<0.05). In the sthenia syndrome group, the dominant syndrome types were blood stasis syndrome in non-restenosis group, and phlegm turbidity syndrome in restenosis group. There was statistical difference in blood stasis syndrome and phlegm turbidity syndrome between the two groups (P<0.05). Conclusion The dominant syndrome types were qi deficiency syndrome and phlegm turbidity syndrome in restenosis after PCI of coronary heart disease. Qi deficiency and phlegm turbidity might be one of the important mechanisms for restenosis after PCI of coronary heart disease.
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Objective To discuss the relationship between Hp eradication effect and TCM syndrome types, and provide basis for improving clinical Hp eradication rate of TCM. Methods TCM syndrome types of 922 Hp-positive patients were distinguished. After treatment by the quadruple chemotherapy, the effect of Hp eradication of different TCM syndrome type was analyzed. Results In 922 Hp infectors, Hp eradication effect in different TCM syndrome type from low to high was as follows:spleen-stomach deficiency-coldness, cold-heat complication, stomach-yin deficiency, congestion of stomach collaterals, hyperactive liver-qi harmful to stomach, liver-stomach heat, spleen-stomach dampness-heat, with significant difference (P0.05). Conclusion The eradication rate of Hp infection was different in patients with different TCM syndrome types, which in deficient syndrome is obviously lower than in excessive syndrome.
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Objectives To study the relationship between TCM syndromes and adiponectin (APN) level, carotid atherosclerosis plaque of hypertension complicated with carotid atherosclerosis, and provide evidence for clinical diagnosis and treatment. Methods One hundred patients of hypertension complicated with carotid atherosclerosis were divided into phlegm syndrome group, stasis syndrome group, and intermingled phlegm and blood stasis syndrome group, and compared with 30 healthy people as control. Carotid atherosclerosis plaque was detected with GE LOGIQ500 color ultrasound system. ELISA was used to determine the serum APN. Results APN of the intermingled phlegm and blood stasis syndrome group was obviously lower than other groups, and there were obvious differences among them. There were more plaques in the intermingled phlegm and blood stasis syndrome group. A negative correlationship was showed between carotid artery intima media thickness (IMT) and APN of hypertension complicated with carotid atherosclerosis. Conclusion There is correlation between TCM syndrome and APN level, carotid atherosclerosis plaque of hypertension complicated with carotid atherosclerosis. The anomalous change of APN and plaque formation of the patients can be preliminarily estimated with the syndrome of TCM.
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Objective To compare the sleep quality and traditional Chinese medical (TCM) syndrome between men and women with cerebral infarction. Method The patients with cerebral infarction enrolled were divided into men patients group and women patients group. After routine treatment of western medicine for 2 weeks, the sleep quality of patients were evaluated with Pittsburgh Sleep Quality Index (PSQI), and the TCM syndrome types were determined by the Diagnostic Criteria of Syndrome Differentiation of Stroke. Result The subjective sleep quality, sleep latency, sleep duration, sleep efficiency, sleep disturbance, use of sleep medication, day-time dysfunction and the overall PSQI scores were higher in the women patients group than that in the men patients group (P
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Objective To observe the change of gastro-intestinal hormone levels about syndrome type of stagnation of liver qi, deficiency of spleen and stomach, liver qi stagnation and spleen qi deficiency in patients with irritable bowel syndrome (IBS), and to probe into the correlation between TCM syndrome type and gastro-intestinal hormone levels. Methods One hundred and three cases of patients with IBS were divided into liver qi stagnation group (35 cases), spleen and stomach deficiency group (30 cases) and liver qi stagnation and spleen qi deficiency group (38 cases), with normal group (10 cases) as control. Plasma motilin (MOT), somatostatin (SS) and cholecystokinin (CCK) were determined by radioimmunoassay. Result The plasma MOT level of spleen and stomach deficiency group was significantly higher than that in the normal controls (P
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liver fire exuberant syndrome. Conclusion Hs-CRP and IMT can be used as important indexes of TCM syndrome differentiation of MS.
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Objective To study the value of CRP and HCY in each TCM type of T2DM with HUA and provide the basis for classification and treatment.Methods 103 cases of T2DM and HUA were divided into four Chinese medicine syndrome groups including deficinecy syndrome of wind-cold and damp-heat phlegm accumlatoin and blood stasis syndrome deficinecy syndrome of Qi and Yin deficinecy syndrome of Yin and yang.Results The differentiation of TCM symptom among four groups was uncorrelated with the level of CRP and Hcy.But the serum CRP and HCY levels increased slighly as compared with those of normal control group.Conclusion The elevation of CRP and Hcy is closely correlated with phlegm accumlation and blood stasis syndrome in patients of T2DM with HUA.As an inflammatoy biomarker,CRP and Hcy may be regard as two of the microcosmic indicators of toxin in Chinese medicine.They can be used as two important indexes of TCM syndrome differentiation of T2DM with HUA.
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0.05). Only the sVCAM-1 level of PILL type had significant difference with the healthy control group and KDDC type (P